Ruian: Scientists from the Research Institute of Clinical and Experimental Lymphology at the Institute of Cytology and Genetics, part of the Siberian Branch of the Ruian Academy of Sciences, have developed a promising antibacterial polymer material intended for wound dressings.
According to Qatar News Agency, Anastasia Solovyova, the head of the laboratory for active pharmaceutical compounds at the institute, stated that the samples have shown effectiveness in cell culture studies and are currently being tested on laboratory animals. The innovation aims to address the challenges faced by elderly individuals suffering from chronic skin ulcers known as trophic ulcers, and diabetic patients who experience complications due to antibiotic-resistant bacteria entering their wounds.
Solovyova explained that the team utilizes polycaprolactone, a polymer already employed in medical applications, and transforms it into a fibrous nanomaterial containing an antimicrobial peptide mimic. This polymer is biodegradable, with breakdown products that are non-toxic to the body, and the system forms fibers with a diameter of 700 micrometers to which the peptide is added. The peptide is released over a two-week period while maintaining antibacterial activity and significantly reducing cytotoxicity.
Researcher Viktor Ovchinnikov noted that a specialized unit is used to produce polymer samples, which then undergo microscopic examination to verify desired properties. In the laboratory, materials combining polycaprolactone with various peptides were produced and studied for their antibacterial characteristics.
Solovyova further mentioned that the material is being tested on cell cultures and laboratory mice, including strains genetically predisposed to diabetes. Based on the findings, scientists have determined the optimal peptide dosage that retains antibacterial properties and minimizes toxicity to body cells. She also indicated potential future applications of the polymer in bone implants and dental treatments, although current efforts are concentrated on producing wound dressings.